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Shake this medication well before using. This medication is usually injected into a joint as directed by your doctor. Methylprednisolone may also be injected Depo-Medrol (methylprednisolone acetate) is used to treat allergies, inflammation, cancer symptoms and flares associated with chronic illnesses. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to DOSAGE AND ADMINISTRATION Because of possible physical incompatibilities, DEPO-MEDROL Sterile Aqueous Suspension should not be diluted or mixed with otherDepo-Medrone should not be mixed with any other suspending agent or solution. When used according to instructions, there is no information to suggest No interactions were found between Depo-Medrol and dexamethasone. However, this does not necessarily mean no interactions exist. Depo-Medrone with Lidocaine should not be mixed with any other When used according to instructions, there is no information to suggest that a change in Methylprednisolone acetate suspension (Depo-Medrol) is intended for IM or intra-articular administration only; do not administer the acetate preparation IV (